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Related Experiment Videos

[Plasmapheresis for patients with RA].

H Tsuda1, M Yokoyama, H Hashimoto

  • 1Juntendo University, Department of Rheumatology.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 1, 1992
PubMed
Summary

Plasmapheresis is a treatment for rheumatoid arthritis (RA) with various procedures and specific indications. However, its overall efficacy for RA requires further investigation through controlled studies.

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Area of Science:

  • Rheumatology
  • Immunology
  • Nephrology

Context:

  • Rheumatoid arthritis (RA) management has utilized plasmapheresis for over a decade.
  • The clinical effectiveness of plasmapheresis in treating RA remains incompletely understood.
  • Various plasmapheresis techniques exist, including plasma exchange, double filtration, cryofiltration, immunoadsorption, and apheresis variants.

Purpose:

  • To review the established efficacy, indications, and procedural methods of plasmapheresis in rheumatoid arthritis patients.
  • To highlight the need for rigorous, controlled studies to definitively assess plasmapheresis efficacy in RA.

Summary:

  • Plasmapheresis encompasses multiple procedures like plasma exchange, double filtration plasmapheresis, and immunoadsorption plasmapheresis.
  • Key indications for plasmapheresis in RA include severe disease, high disease activity, presence of immune complexes, and intolerance to standard therapies.
  • The current literature lacks robust data on plasmapheresis effectiveness, necessitating controlled trials.

Impact:

  • This review underscores the importance of evidence-based practice in applying plasmapheresis for rheumatoid arthritis.
  • It identifies critical gaps in knowledge regarding plasmapheresis efficacy, guiding future research directions.
  • The findings aim to inform clinical decision-making and optimize treatment strategies for RA patients.

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