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Published on: June 11, 2012
Adherence to oral hypoglycemic agents in Hawaii
1John A. Burns School of Medicine, 2015 Mott-Smith Dr, Honolulu, HI 96822, USA. rachell@hawaii.edu
Insights
Adherence to oral hypoglycemic agents was lowest in younger and Filipino patients in Hawaii. This finding is crucial for developing targeted interventions to improve medication adherence and health outcomes in these populations.
Area of Science:
- Endocrinology
- Public Health
- Health Services Research
Background:
- Adherence to oral hypoglycemic agents (OHAs) is critical for managing diabetes and preventing complications.
- Identifying patient characteristics associated with low adherence is key to improving population health outcomes.
Purpose of the Study:
- To identify patient characteristics in Hawaii associated with low adherence to oral hypoglycemic agents.
- To inform targeted interventions for improving OHA adherence.
Main Methods:
- Retrospective analysis of prescription refill claims for OHAs from 1999-2003 (n=20,685).
- Multivariate logistic regression used to examine the relationship between adherence and patient characteristics.
Main Results:
- Adherence varied significantly by age and ethnicity.
- Adherence peaked at age 74 and declined after age 85.
- Japanese patients had the highest adherence, while Filipino patients had the lowest, relative to white patients. Gender showed no association.
Conclusions:
- Ethnicity and age are significant factors influencing OHA adherence.
- Younger and Filipino patients represent key target groups for interventions to improve adherence.
- Targeted strategies are needed to address disparities in OHA adherence and improve glycemic control and health outcomes.
Introduction:
Adherence to oral hypoglycemic agents is essential to reducing the poor health outcomes of populations at high risk for developing diabetes and its chronic complications. The goal of this study was to identify characteristics of patients in Hawaii least likely to adhere to oral hypoglycemic agents.
Methods:
This retrospective administrative data analysis included prescription refill claims for oral hypoglycemic agents from January 1, 1999, through June 30, 2003 (n = 20,685). Multivariate logistic regression analysis was used to examine the relationship between adherence and patient characteristics.
Results:
Adherence was found to be strongly associated with age and ethnicity. Relative to the age subset 55 to 64 years, adherence increased as age increased, reaching a peak at age 74 (odds ratio [OR] 1.1; 95% confidence interval [CI], 1.0-1.20). Past the age of 85, adherence declined (OR 0.90; 95% CI, 0.82-0.98). Relative to white patients, the odds ratio of adherence was highest for Japanese patients (OR 1.20; 95% CI, 1.0-1.30) and lowest for Filipino patients (OR 0.78; 95% CI, 0.68-0.90). Gender was not associated with adherence.
Conclusion:
Differences in adherence to oral hypoglycemic agents were found to be related to ethnicity and age. Adherence was found to be lowest in younger patients and Filipino patients. This is a significant finding considering that younger diabetic patients have been shown to have the poorest glycemic control and worst health outcomes. Although the literature on adherence to oral hypoglycemic agents and health outcomes in Filipino patients is limited, studies support an increased risk for developing diabetes in this group. This information can be used to target younger patients and Filipino patients to improve their adherence to oral hypoglycemic agents.
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