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Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians
Elena Cellini1, Benedetta Nacmias, Fabiola Olivieri
1Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
Abstract:
A common polymorphism (I405V) in exon 14 of the cholesteryl ester transfer protein (CETP) gene has been recently associated to healthy aging in Ashkenazi Jewish. In order to study this genetic effect in long-lived individuals with a different ethnicity, we analyzed the allele and genotype distributions of the CETP polymorphism a sample of Italian centenarians. Our result does not confirm the association between the I405V CETP variation and the healthy aging phenotype described in the Ashkenazi Jewish population and suggests that other gene environment interactions contribute to longevity.
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