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Related Experiment Videos

Hepatitis due to nitrofurantoin.

L C Mollison1, P Angus, M Richards

  • 1Austin Hospital, Heidelberg, VIC.

The Medical Journal of Australia
|March 2, 1992
PubMed
Summary

Nitrofurantoin can cause severe liver injury, including fatal hepatitis. Continued use despite liver damage is dangerous, necessitating careful monitoring of liver function during long-term nitrofurantoin therapy.

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Area of Science:

  • Hepatology
  • Pharmacology
  • Toxicology

Background:

  • Nitrofurantoin is a commonly prescribed antibiotic for urinary tract infections.
  • Long-term use of nitrofurantoin has been associated with various adverse effects, including pulmonary and hepatic toxicity.

Observation:

  • Three cases of nitrofurantoin-induced hepatitis are presented.
  • Two patients developed severe liver failure after years of nitrofurantoin use, with the drug continued despite signs of liver injury.
  • A third patient experienced acute hepatitis after six weeks of therapy.

Findings:

  • One patient with liver failure died; another required a liver transplant.
  • The third patient recovered fully after discontinuing nitrofurantoin.
  • These cases highlight the spectrum of hepatic reactions to nitrofurantoin.

Implications:

  • Clinicians should be vigilant for potential serious hepatic reactions to nitrofurantoin.
  • Discontinuation of nitrofurantoin is crucial upon evidence of liver injury.
  • Regular monitoring of liver function is essential for patients on long-term nitrofurantoin treatment.

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