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Related Experiment Videos

Epilepsy and apoptosis pathways.

David C Henshall1, Roger P Simon

  • 1Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland. dhenshall@rcsi.ie

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|May 13, 2005
PubMed
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Apoptosis, a programmed cell death pathway, is activated by seizures and contributes to brain injury and epilepsy development. Understanding this process offers new therapeutic targets for seizure damage.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Epilepsy is a chronic neurological disorder marked by recurrent seizures.
  • Seizures can cause neuronal death, potentially leading to cognitive impairments and epilepsy progression.
  • Apoptosis, or programmed cell death, is a key molecular pathway involved in seizure-induced neuronal injury.

Purpose of the Study:

  • To review clinical and experimental evidence of apoptosis in seizure-induced neuronal death.
  • To summarize the roles of intrinsic and extrinsic apoptotic pathways, caspases, and Bcl-2 family proteins.
  • To explore the implications of apoptosis in epileptogenesis and potential therapeutic strategies.

Main Methods:

  • Review of existing clinical and experimental research on apoptosis after seizures.

Related Experiment Videos

  • Analysis of data on intrinsic (mitochondrial) and extrinsic (death receptor) apoptotic pathways.
  • Examination of the roles of caspase and Bcl-2 family proteins in neuronal cell death.

    • Main Results:

    • Seizure activity activates both intrinsic and extrinsic apoptotic pathways.
    • Caspase and Bcl-2 family proteins are key modulators of cell death following seizures.
    • Intervention in these pathways impacts acute and chronic neuropathology.
    • Apoptotic proteins also play nonlethal roles in neuronal restructuring and excitability.

    Conclusions:

    • Apoptosis signaling is crucial in seizure-induced neuronal death and epileptogenesis.
    • Emerging roles of apoptosis proteins in brain remodeling and excitability offer novel therapeutic avenues.
    • Targeting apoptosis pathways presents strategies for protecting against seizure damage and epilepsy development.