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Updated: Aug 18, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
(S,S)-(+)-pseudoephedrine as chiral auxiliary in asymmetric acetate aldol reactions
Mónica Rodríguez1, Jose L Vicario, Dolores Badía
1Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, P.O. Box 644, 48080, Bilbao, Spain.
Abstract:
The asymmetric acetate-type aldol reaction using (S,S)-(+)-pseudoephedrine has been studied in detail. Experimental variables like the nature of the metal counterion of the enolate, the presence of additives and the structure of the aldehyde have been examined in order to reach to the highest possible yields and diastereoselectivities.
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