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Updated: Aug 10, 2026

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
Free radicals in myocardial injury: experimental and clinical studies
N K Ganguly1, K Nalini, S Wahi
1Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Abstract:
The exposure of cardiac cells to OFR generated artificially, showed a marked decrease (p less than 0.01) in cellular utilization of glucose along with a significant decrease in calcium uptake (p less than 0.05). We have also provided evidence for a direct relationship of neutrophil OFR production with the extent of myocardial ischemia in patients of myocardial infarction. Our data provides evidence for implication of OFR in myocardial injury and the pivotal role played by modulators like calcium, ECGF and prostaglandins in potentiating damage to the myocardium.
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