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Orthopaedic infections: organisms and antibiotic sensitivity

M I Yusof1, A H Yusof

  • 1Department of Orthopaedics, School of Medical Sciences, Health Campus, USM, Kelantan, Malaysia.

The Medical Journal of Malaysia
|May 14, 2005
PubMed

Insights

Staphylococcus aureus is a common cause of musculoskeletal infections. Local antibiotic resistance surveillance is crucial, as this study found high sensitivity to cloxacillin for S. aureus and vancomycin for MRSA.

Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Microbiology

Background:

  • Staphylococcus aureus is the most frequent cause of musculoskeletal infections.
  • Antibiotic resistance in orthopaedic practice is a growing concern due to widespread antibiotic use.
  • Antibiotic sensitivity patterns vary geographically, necessitating local surveillance.

Purpose of the Study:

  • To assess the prevalence of Staphylococcus aureus in musculoskeletal infections.
  • To determine the antibiotic sensitivity patterns of S. aureus, including methicillin-resistant strains (MRSA).
  • To inform local treatment guidelines for musculoskeletal infections.

Main Methods:

  • Retrospective study of 66 patients with musculoskeletal infections.
  • Bacteriological analysis to identify causative organisms.
  • Antibiotic susceptibility testing was performed on isolated S. aureus strains.

Main Results:

  • Staphylococcus aureus was identified in 50-65% of patients.
  • Methicillin-resistant Staphylococcus aureus (MRSA) accounted for 15% of S. aureus isolates.
  • S. aureus showed 95% sensitivity to cloxacillin; MRSA remained sensitive to vancomycin, clindamycin, and fucidic acid.

Conclusions:

  • Local surveillance of antibiotic resistance is essential for effective treatment of S. aureus musculoskeletal infections.
  • Cloxacillin is a highly effective antibiotic for susceptible S. aureus infections.
  • Vancomycin, clindamycin, and fucidic acid are effective options for MRSA infections.

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