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Updated: Aug 18, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells
Published on: October 14, 2015
[Immunologic characteristics of tumor-derived vascular endothelial cells]
Wen-Jian Zhang1, Lian-Qiu Wu, Li-Ya Ye
1Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, P. R. China. lou.j@mail.com.
Abstract:
Tumor vessel plays an important role in development of tumor, because they supply tumor not only nutrition but also a way of metastasis. Since tumor-derived vascular endothelial cells chronically emerge in tumor microenvironment, their phenotypes and functions have significantly changed, including some immunologic characteristics, such as down-regulated adhesion molecules, diminished leukocyte-endothelium interactions, impaired antigen presentation, enhanced resistant activity to free radicals, and synthesis of a great amount of extracellular matrix. Because tumor-derived vascular endothelial cell is the first barrier for immune cells and immune drugs to enter tumor tissue, these changes of immunologic characteristics of tumor- derived vascular endothelial cells may be related to the mechanisms of tumor cells escaping from host's immune surveillance and immune killing. This review summarized the immunologic characteristics of tumor-derived vascular endothelial cells, and analyzed the relationship between these characteristics and tumor immune escape.
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