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Published on: June 25, 2019
Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals
Nicolas Chartrel1, Federica Bruzzone, Cynthia Dujardin
1European Institute for Peptide Research (IFRMP 23), Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, University of Rouen, Mont-Saint-Aignan, France. nicolas.chartrel@univ-rouen.fr
Abstract:
In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior. Intracerebroventricular injection of 26RFa in mice induced a dose-dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.
