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Published on: January 12, 2015
Molecular evolution and subfunctionalization of Nkx2.1 in the rainbow trout
Masakazu Suzuki1, Yoshie Hidaka, Youji Uemae
1Department of Biology, Faculty of Science, Shizuoka University, Japan. sbmsuzu@ipc.shizuoka.ac.jp
Abstract:
Because specification of duplicated genes is considered to be a major driving force for diversity and evolution, it is important to understand the function of the duplicated genes. In mammals, Nkx2.1 is essential for the differentiation of thyroid follicular cells and for the transcription of thyroid-specific genes. We have cloned four distinct Nkx2.1 cDNAs from the rainbow trout, Oncorhynchus mykiss. In the present article, we will characterize the trout Nkx2.1 mRNAs and show their tissue distribution, their transcriptional activities, and their expression during early development.
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