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Related Experiment Videos

Accidental clonidine patch ingestion in a child.

Russ Horowitz1, Suzan S Mazor, Steven E Aks

  • 1Pediatric Emergency Medicine, Children's Memorial Hospital, Chicago, Illinois 60026, USA.

American Journal of Therapeutics
|May 14, 2005
PubMed
Summary

Pediatric clonidine patch ingestion caused lethargy, bradycardia, and miosis. Aggressive decontamination, including naloxone and charcoal, is crucial for managing toxicity from gastrointestinal absorption.

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Area of Science:

  • Toxicology
  • Pediatric Emergency Medicine

Background:

  • Clonidine patches are a transdermal drug delivery system.
  • Pediatric ingestion of transdermal patches poses unique toxicological challenges due to prolonged drug absorption.

Observation:

  • A pediatric patient presented with significant toxicity after ingesting a clonidine patch.
  • Clinical manifestations included central nervous system depression (lethargy), cardiovascular effects (bradycardia), and pupillary changes (miosis).

Findings:

  • Gastrointestinal absorption of clonidine from the patch led to severe systemic toxicity.
  • Treatment involved a multi-modal approach including naloxone, activated charcoal, and whole bowel irrigation.

Implications:

  • Prompt recognition and aggressive decontamination are vital for managing clonidine patch ingestion in children.

Related Experiment Videos

  • This case highlights the potential for severe toxicity and underscores the importance of targeted treatment strategies.