Rare skin disorder complicating doxorubicin therapy: miliaria crystallina

Miliaria is a self-resolving disorder of the eccrine sweat glands caused by blockage of the sweat ducts resulting in the leakage of eccrine sweat into epidermis or dermis. In addition to known predisposing factors such as heat, humidity, and fever, a few drugs (eg, isotretinoin and bethanechol) can also precipitate miliaria. We present here a case of miliaria crystallina that developed in a 65-year-old patient on the fifth day after administration of doxorubicin for multiple myeloma in the absence of known predisposing factors. Miliaria crystallina resolved in 3 days without any complications. To our knowledge, this is the first reported case of doxorubicin-induced miliaria crystallina.