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Related Experiment Videos

Lipolysis: pathway under construction.

Rudolf Zechner1, Juliane G Strauss, Guenter Haemmerle

  • 1Institute of Molecular Biosciences, Karl-Franzens University Graz, Graz, Austria. rudolf.zechner@uni-graz.at

Current Opinion in Lipidology
|May 14, 2005
PubMed
Summary
This summary is machine-generated.

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A newly discovered enzyme, adipose triglyceride lipase, plays a key role in breaking down stored fat for energy. This finding challenges the long-held belief that hormone-sensitive lipase is the sole enzyme responsible for fat mobilization.

Area of Science:

  • Biochemistry
  • Metabolism
  • Lipidomics

Background:

  • Adipose tissue stores fat, releasing fatty acids during fasting for energy.
  • Hormone-sensitive lipase was previously considered the primary enzyme for fat breakdown.

Purpose of the Study:

  • To review the role of newly discovered enzymes in adipose tissue lipolysis.
  • To understand fatty acid mobilization and energy substrate supply during food deprivation.

Main Methods:

  • Characterization of hormone-sensitive lipase-deficient mice.
  • Independent discovery and characterization of a novel triglyceride hydrolase.
  • Analysis of enzyme regulation by nutritional status.

Main Results:

  • Hormone-sensitive lipase is not the only enzyme hydrolyzing stored triglycerides and diglycerides.

Related Experiment Videos

  • A novel enzyme, adipose triglyceride lipase (ATGL), was discovered, predominantly expressed in adipose tissue.
  • ATGL exhibits substrate specificity for triglycerides and is regulated by nutritional status, potentially having acyl-transacylase activity.

    • Conclusions:

    • Adipose triglyceride lipase is involved in cellular fatty acid mobilization.
    • The discovery of ATGL necessitates a revision of the concept that hormone-sensitive lipase is solely responsible for adipose triglyceride lipolysis.