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Updated: Aug 5, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Proton magnetic resonance spectroscopy and diffusion-weighted imaging of central nervous system whipple disease
Jared W Nelson1, Matthew L White, Yan Zhang
1University of Iowa College of Medicine, Iowa City, IA 52246, USA. jared-nelson@uiowa.edu
Abstract:
A 72-year-old man presented with a 6-month history of dysphagia, fatigue, 60-lb weight loss, and central nervous system (CNS) deficits. Diffusion-weighted magnetic resonance imaging (MRI) of the brain showed mildly elevated nonrestricted apparent diffusion coefficients in the middle cerebellar peduncles, and magnetic resonance spectroscopy (MRS) showed decreased N-acetylaspartate and creatine with increased choline. Diffusion-weighted MRI and MRS offer noninvasive methods to help evaluate in vivo physiologic changes of CNS involvement in Whipple disease.

