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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Assessment of global left ventricular function: comparison of cardiac multidetector-row computed tomography with

Walter Hundt1, Karen Siebert, Bernd J Wintersperger

  • 1Department of Clinical Radiology, University of Munich, Munich, Germany. walter.hundt@web.de

Journal of Computer Assisted Tomography
|May 14, 2005
PubMed

Insights

Electrocardiogram (ECG)-gated multidetector row CT (MDCT) can assess left ventricular function. The 3D method shows the highest correlation with invasive ventriculography, but significantly overestimates end-systolic volumes, underestimating stroke volume and ejection fraction.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Radiology

Background:

  • Assessing left ventricular (LV) function is crucial for diagnosing and managing cardiovascular diseases.
  • Invasive ventriculography (LVG) is a standard method for evaluating LV function, but it is invasive.
  • Non-invasive imaging techniques like ECG-gated MDCT offer a potential alternative for LV function assessment.

Purpose of the Study:

  • To evaluate the accuracy of three different volumetric assessment methods using ECG-gated MDCT for determining left ventricular function.
  • To compare the MDCT-derived volumetric data with measurements obtained from invasive left ventriculography.

Main Methods:

  • Thirty patients with suspected or known coronary artery disease underwent ECG-gated MDCT coronary angiography.
  • Left ventricular volumes were calculated using three methods: 3D dataset, hemisphere cylinder (HC), and biplane ellipsoid (BE).
  • Calculated end-diastolic volumes (EDV), end-systolic volumes (ESV), stroke volumes (SV), and ejection fractions (EF) were compared to LVG measurements.

Main Results:

  • The 3D method demonstrated good correlation with LVG for EDV (r=0.73), ESV (r=0.88), and EF (r=0.76).
  • While EDV measurements did not differ significantly, the 3D method showed significant overestimation of ESV (P<0.01), leading to underestimation of SV and EF (P<0.01).
  • The HC method resulted in the most substantial overestimation of LV volumes compared to LVG.

Conclusions:

  • ECG-gated MDCT can be used to calculate left ventricular volumes and estimate systolic function.
  • The 3D volumetric method shows the highest correlation with invasive ventriculography.
  • Significant overestimation of ESV by MDCT necessitates caution when interpreting SV and EF values.
Abstract

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