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Large-scale integrated databases supporting drug discovery.

Alan H Roter1

  • 1Iconix Pharmaceuticals Inc, 325 East-Middlefield Road, Mountain View, CA 94061, USA. aroter@iconixpharm.com

Current Opinion in Drug Discovery & Development
|May 17, 2005
PubMed
Summary

Genomics and automation created data-rich drug discovery. Integrated chemogenomic databases now convert this data into actionable information for small-molecule drug discovery.

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Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.

Journal of biotechnology·2005

Area of Science:

  • Bioinformatics
  • Drug Discovery Informatics
  • Cheminformatics

Background:

  • Drug discovery has shifted from information-poor to data-rich over 15 years due to advances in genomics, combinatorial chemistry, and high-throughput automation.
  • The key challenge for informatics scientists is integrating and utilizing the vast amounts of disparate data generated.
  • Effective data consolidation requires expertise in database technology, standardized data formats, and existing data systems.

Purpose of the Study:

  • To highlight the transformative potential of integrated chemogenomic databases in drug discovery.
  • To emphasize the need for informatics solutions to manage and leverage big data in pharmaceutical research.

Main Methods:

  • Review of technological advancements in drug discovery data generation.
  • Analysis of data integration challenges and requirements.
  • Introduction of chemogenomic databases as an integrated solution.

Main Results:

  • Chemogenomic databases are emerging as the first truly integrated systems.
  • These databases directly link 'omic' data with small-molecule drug discovery efforts.
  • Researchers can now access new information domains through these integrated systems.

Conclusions:

  • Integrated chemogenomic databases are crucial for converting 'omic' data into valuable insights for drug discovery.
  • The adoption of these databases empowers researchers to leverage advanced information domains.
  • This represents a significant step forward in data-driven small-molecule drug discovery.

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