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Published on: December 9, 2022
Isodomoic acid C, an unusual amnesic shellfish poisoning toxin from Pseudo-nitzschia australis
Patrick T Holland1, Andrew I Selwood, Douglas O Mountfort
1Cawthron Institute, Private Bag 2, Nelson, New Zealand. patrick.holland@cawthron.org.nz
Abstract:
An unusual isomer of domoic acid (1), isodomoic acid C (2), has been found in New Zealand shellfish contaminated by amnesic shellfish poisoning (ASP) toxins and was shown to be produced by a local strain of the pennate diatom Pseudo-nitzschia australis. A bulk culture of this strain was used to isolate 2. The structure was determined from spectroscopic data and was shown to correspond to that of 2 from a Japanese red seaweed, the only other reported occurrence of this compound. The affinity of 2 for GluR6 glutamate receptors was 240-fold lower than for 1, indicating low neurotoxic potential.
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