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Updated: Aug 18, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Peptoids as source of compounds eliciting antibacterial activity
Isabel Masip1, Enrique Pérez-Payá, Angel Messeguer
1Department of Biological Organic Chemistry, IIQAB (CSIC) J. Girona, 18. E-08034 Barcelona, Spain.
Abstract:
N-Alkylglycine oligomers (peptoids) constitute a family of non-natural peptidomimetics attractive for the early drug discovery process because of their physicochemical features, easy of adaptation to combinatorial chemistry approaches and their proteolytic stability. Consequently, peptoid libraries have found application for discovering hits against a wide diversity of pharmaceutical targets, among which different examples of antibacterials are found. In the present work, research efforts addressed towards the identification of peptoids as antibacterial agents are discussed.
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