Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Target-related affinity profiling: Telik's lead discovery technology.

Paul Beroza1, Komath Damodaran, Robert T Lum

  • 1Telik, Inc., 3165 Porter Dr., Palo Alto, CA 94304, USA. pberoza@telik.com

Current Topics in Medicinal Chemistry
|May 17, 2005
PubMed
Summary

Target-Related Affinity Profiling (TRAP) offers a novel computational drug discovery method using affinity fingerprints. This approach aids in identifying new drug leads by analyzing protein binding preferences, complementing traditional techniques.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model.

Nature communications·2026
Same author

Utilizing Molecular Dynamics and Mechanistic Pharmacokinetic Studies in the Design of Selective CDK2 Inhibitors.

Journal of medicinal chemistry·2026
Same author

Shape-Aware Synthon Search (SASS) for Virtual Screening of Synthon-Based Chemical Spaces.

Journal of chemical information and modeling·2024
Same author

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance.

Nature cancer·2023
Same author

Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors.

Nature communications·2022
Same author

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.

Cell reports·2020

Area of Science:

  • Computational drug discovery
  • Medicinal chemistry
  • Pharmacology

Background:

  • Traditional drug lead discovery relies on chemical structure-based descriptors.
  • Limitations exist in traditional methods for identifying novel drug candidates.
  • Target-Related Affinity Profiling (TRAP) utilizes protein binding preferences as molecular descriptors.

Purpose of the Study:

  • To review the concepts and applications of Target-Related Affinity Profiling (TRAP).
  • To compare affinity fingerprints with traditional structure-based molecular descriptors.
  • To demonstrate TRAP's utility in discovering novel inhibitors for specific enzymes.

Main Methods:

  • Review of underlying concepts of TRAP and affinity fingerprints.
  • Comparison of affinity fingerprints to structure-derived molecular descriptors.

Related Experiment Videos

  • Description of the TRAP screening process with two case studies.

    • Main Results:

    • Affinity fingerprints are a valuable alternative to structure-based descriptors for lead discovery.
    • TRAP successfully identified novel inhibitors for human intestinal carboxylesterase.
    • TRAP facilitated the discovery of novel cyclooxygenase-1 inhibitors using known inhibitor fingerprints.

    Conclusions:

    • TRAP is a powerful computational drug discovery technology.
    • Affinity fingerprints offer complementary advantages over traditional drug lead discovery approaches.
    • TRAP enhances the identification of novel therapeutic agents.