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Components of successful lead generation.

Andrew M Davis1, David J Keeling, John Steele

  • 1Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH UK.

Current Topics in Medicinal Chemistry
|May 17, 2005
PubMed
Summary

This review outlines best practices for lead generation, focusing on assembling compound collections for High Throughput Screening (HTS). It covers HTS execution, data profiling, and optimizing screening hits into lead compounds.

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Area of Science:

  • Drug Discovery and Medicinal Chemistry
  • Chemical Biology

Background:

  • Effective lead generation is crucial for pharmaceutical research and development.
  • Current literature offers limited peer-reviewed insights into practical lead generation strategies.
  • This review synthesizes author experiences from numerous campaigns.

Purpose of the Study:

  • To provide an overview of current good practices in lead generation.
  • To assess and report on experiences in lead generation within the field.
  • To focus on key stages of the lead generation process.

Main Methods:

  • Review of existing peer-reviewed literature on lead generation.
  • Analysis of internal organizational experiences and campaign data.
  • Focus on compound collection assembly for High Throughput Screening (HTS).

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Main Results:

  • Detailed examination of High Throughput Screening (HTS) prosecution.
  • Assessment of methods for profiling HTS output.
  • Evaluation of Hit-to-Lead optimization strategies for selected HTS outputs.

Conclusions:

  • Best practices in lead generation involve strategic compound collection and effective HTS execution.
  • Profiling HTS output and Hit-to-Lead optimization are critical for successful drug discovery.
  • This review consolidates practical knowledge to guide future lead generation efforts.