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Intercellular trafficking activity of herpes simplex virus US11 gene product in the mouse brain

Isamu Mori1, Tetsuo Koshizuka, Fumi Goshima

  • 1Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Aichi 480-1195, Japan. isamor@aichi-med-u.ac.jp

Brain Research. Molecular Brain Research
|May 17, 2005
PubMed

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Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...