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Updated: Aug 18, 2026

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast
Published on: January 26, 2017
Epigenetic silencing mechanisms in budding yeast and fruit fly: different paths, same destinations
Vincenzo Pirrotta1, David S Gross
1Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA. pirrotta@biology.rutgers.edu
Abstract:
Transcriptional silencing in budding yeast and fruit fly is mediated by fundamentally unrelated proteins that assemble very different chromatin structures. Surprisingly, the repressive mechanisms evolved from these very different materials have similar features, including an epigenetic mode of inheritance and a block to transcription based on interference with the assembly or function of the promoter complex rather than with the binding of gene-specific activators.
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