Related Experiment Videos
Preliminary pharmacological studies on Piper chaba stem bark
Md Taufiq-Ur-Rahman1, Jamil Ahmad Shilpi, Muniruddin Ahmed
1School of Biological Sciences, University of Manchester, Oxford Road, M13 9PL Manchester, UK. mtrahmanbd@yahoo.com
Journal of Ethnopharmacology
|May 17, 2005
Summary
The methanol extract of Piper chaba stem bark demonstrated significant analgesic, anti-inflammatory, anti-diarrhoeal, and CNS depressant effects in animal models. It also showed moderate diuretic activity at higher doses, supporting its traditional medicinal uses.
Area of Science:
- Pharmacology
- Ethnomedicine
- Natural Product Chemistry
Background:
- Piper chaba Hunter (Piperaceae) is a widely used plant in traditional Ayurvedic medicine.
- Its ethnomedicinal applications for various ailments necessitate scientific validation.
Purpose of the Study:
- To investigate the pharmacological activities of the methanol extract of Piper chaba stem bark.
- To rationalize the traditional uses of Piper chaba in treating pain, inflammation, diarrhea, and other conditions.
Main Methods:
- Preliminary pharmacological evaluation of Piper chaba stem bark methanol extract in mice and rats.
- Assessed analgesic, anti-inflammatory, diuretic, anti-diarrhoeal, gastrointestinal motility, and CNS depressant activities at doses of 125, 250, and 500 mg/kg.
Main Results:
- The extract exhibited significant dose-dependent reduction in acetic acid-induced writhing and carrageenan-induced paw edema.
- Demonstrated prolonged tail flicking latency, delayed castor oil-induced diarrhea, decreased gastrointestinal motility, and prolonged pentobarbitone-induced sleeping time.
- Moderate diuretic activity was observed only at the highest dose (500 mg/kg).
Conclusions:
- The methanol extract of Piper chaba stem bark possesses significant analgesic, anti-inflammatory, anti-diarrhoeal, and CNS depressant properties.
- These findings provide scientific evidence supporting the traditional ethnomedicinal uses of Piper chaba.