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Fibrates and coronary risk reduction.
1Division of Endocrinology and Metabolism, Toronto General Hospital, 200 Elizabeth Street, University of Toronto, Toronto, Ontario, Canada M5G 2C4. george.steiner@uhn.on.ca
Atherosclerosis
|May 17, 2005
Summary
Fibrates are a class of medications used to manage lipid disorders when lifestyle changes are insufficient. This review examines their effectiveness in treating coronary artery disease.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
Background:
- Lipoprotein abnormalities often require pharmacologic intervention beyond lifestyle modifications.
- Current treatments do not address all types of dyslipidemia comprehensively.
Purpose of the Study:
- To review the role of fibrates in managing lipid disorders.
- To summarize clinical trial data on fibrates' impact on coronary artery disease.
Main Methods:
- Literature review of clinical trials and studies on fibrates.
- Analysis of data concerning lipid management and cardiovascular outcomes.
Main Results:
- Fibrates are a key therapeutic class for specific lipoprotein abnormalities.
- Clinical trial evidence is summarized regarding their effect on coronary artery disease.
Conclusions:
- Fibrates play a significant role in the pharmacologic management of dyslipidemia.
- Their impact on coronary artery disease outcomes is a critical consideration in clinical practice.