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Published on: November 10, 2017

Fibrates and coronary risk reduction

George Steiner1

  • 1Division of Endocrinology and Metabolism, Toronto General Hospital, 200 Elizabeth Street, University of Toronto, Toronto, Ontario, Canada M5G 2C4. george.steiner@uhn.on.ca

Atherosclerosis
|May 17, 2005
PubMed

Insights

Fibrates are a class of medications used to manage lipid disorders when lifestyle changes are insufficient. This review examines their effectiveness in treating coronary artery disease.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Lipoprotein abnormalities often require pharmacologic intervention beyond lifestyle modifications.
  • Current treatments do not address all types of dyslipidemia comprehensively.

Purpose of the Study:

  • To review the role of fibrates in managing lipid disorders.
  • To summarize clinical trial data on fibrates' impact on coronary artery disease.

Main Methods:

  • Literature review of clinical trials and studies on fibrates.
  • Analysis of data concerning lipid management and cardiovascular outcomes.

Main Results:

  • Fibrates are a key therapeutic class for specific lipoprotein abnormalities.
  • Clinical trial evidence is summarized regarding their effect on coronary artery disease.

Conclusions:

  • Fibrates play a significant role in the pharmacologic management of dyslipidemia.
  • Their impact on coronary artery disease outcomes is a critical consideration in clinical practice.

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