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Published on: April 17, 2021

Depression and heart failure in patients with a new myocardial infarction

Lynda H Powell1, Diane Catellier, Kenneth E Freedland

  • 1Department of Preventive Medicine, Rush University Medical Center, Chicago, Ill 60614, USA. lpowell@rush.edu

American Heart Journal
|May 17, 2005
PubMed

Insights

Major depression is more common in heart failure (HF) patients hospitalized with myocardial infarction (MI). Early diagnosis and treatment of depression in HF patients post-MI are crucial for better outcomes.

Area of Science:

  • Cardiology
  • Psychiatry
  • Public Health

Background:

  • Heart failure (HF) is a growing chronic illness with increasing prevalence.
  • Psychosocial factors in HF patients are not well understood.
  • This study examines depression in myocardial infarction (MI) patients with and without HF.

Purpose of the Study:

  • To compare depression prevalence in hospitalized MI patients with and without heart failure.
  • To identify the association between major depression and heart failure in post-MI patients.
  • To assess the impact of psychosocial risk on depression in HF patients.

Main Methods:

  • Utilized baseline data from 2444 participants in the ENRICHD clinical trial.
  • Assessed depression using DSM-IV criteria within 28 days of MI.
  • Diagnosed HF based on left ventricular dysfunction or history, and collected demographic/medical confounders.

Main Results:

  • Heart failure was present in 34.7% of participants (847 patients).
  • Major depression occurred in 43% of HF patients versus 36% in non-HF patients (P < .001).
  • Major depression increased the odds of HF by 38% (adjusted OR 1.38, 95% CI 1.09-1.76).

Conclusions:

  • Major depression is more prevalent in post-MI patients with co-existing heart failure.
  • Depression negatively impacts treatment adherence and quality of life in HF patients.
  • Targeted diagnosis and treatment of depression in HF patients post-MI are recommended.
Abstract

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