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Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells
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Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1

Zhe Li1, Frank J Godinho, Jan-Henning Klusmann

  • 1Division of Hematology/Oncology, Childrens Hospital, Boston, Massachusetts 02115, USA.

Nature Genetics
|May 17, 2005
PubMed
Summary

Acquired mutations in GATA1 cause a truncated protein (GATA1s) linked to Down syndrome-related leukemias. This variant GATA1s drives progenitor cell hyperproliferation, explaining transient myeloproliferative disorder and infant leukemia.

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