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Rosai-Dorfman disease presenting as multiple soft tissue masses
Phillip M Young1, Mark J Kransdorf, H Thomas Temple
1Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224-3899, USA. kransdorf.mark@mayo.edu
Skeletal Radiology
|May 17, 2005
Summary
Rosai-Dorfman disease, a rare disorder, can manifest as isolated soft tissue masses. This case highlights the importance of considering this condition in the differential diagnosis of multiple cutaneous lesions.
Area of Science:
- Dermatology
- Pathology
- Radiology
Background:
- Rosai-Dorfman disease is a rare histiocytic proliferative disorder.
- Classically affects lymph nodes, but extranodal and soft tissue involvement is recognized.
- Cutaneous Rosai-Dorfman disease can present without systemic or nodal involvement.
Observation:
- A patient presented with multiple, superficial soft tissue masses.
- Magnetic resonance (MR) imaging revealed two well-defined, intensely enhancing, nonspecific masses.
- Biopsy confirmed the masses as isolated cutaneous Rosai-Dorfman disease.
Findings:
- Soft tissue involvement in Rosai-Dorfman disease can be multifocal.
- Isolated cutaneous Rosai-Dorfman disease may mimic other soft tissue tumors.
- Intense enhancement on MR imaging is a characteristic finding.
Implications:
- Rosai-Dorfman disease should be included in the differential diagnosis for patients with multiple soft tissue masses.
- Early recognition can prevent misdiagnosis and guide appropriate management.
- Further research into the imaging characteristics of cutaneous Rosai-Dorfman disease is warranted.