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Pulmonary function in microgravity.

H J Guy1, G K Prisk, J B West

  • 1Department of Medicine, University of California, San Diego, La Jolla 92093-0931.

The Physiologist
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

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Human pulmonary function data collected on the SLS-1 mission reveal high cardiac stroke volumes in orbit. Lung function adaptations occur over several days, with gravitational gradients having a modest impact on tests like single breath nitrogen washout.

Area of Science:

  • Cardiovascular Physiology
  • Respiratory Physiology
  • Space Medicine

Background:

  • Understanding human physiological adaptation to microgravity is crucial for long-duration spaceflight.
  • Pulmonary function is known to be affected by gravity, but the extent of these effects in microgravity is not fully understood.
  • Previous studies have indicated changes in cardiovascular and respiratory systems during spaceflight.

Purpose of the Study:

  • To collect and analyze human resting pulmonary function data during the SLS-1 mission.
  • To investigate the impact of microgravity on cardiac stroke volume, pulmonary capillary blood volume, and lung function gradients.
  • To assess the influence of gravitational gradients on pulmonary function tests in microgravity.

Main Methods:

  • Collection of human resting pulmonary function data on the SLS-1 mission.
Keywords:
NASA Discipline CardiopulmonaryNASA Experiment Number 178198 1/2Non-NASA Center

Related Experiment Videos

  • Preliminary analysis of cardiac stroke volumes and pulmonary capillary blood volumes.
  • Evaluation of single breath nitrogen (SBN) washouts and their phase III slope.
  • Analysis of cardiogenic and CO2 oscillations in expired gas during microgravity.

    • Main Results:

    • Cardiac stroke volumes were found to be high in orbit, with adaptive reduction taking several days.
    • Pulmonary capillary blood volumes were high and remained elevated in microgravity, without significant impact on the pulmonary interstitium.
    • Gravitational gradients influenced single breath tests like SBN washout only modestly (approx. 25% of phase III slope).
    • Phase relationships of CO2 oscillations reversed in microgravity, suggesting a role for non-gravitational mechanisms.

    Conclusions:

    • Microgravity alters cardiac and pulmonary hemodynamics, requiring several days for adaptation.
    • Gravitational gradients play a moderate role in lung function tests and gas oscillations.
    • Microgravity serves as a valuable tool for studying non-gravitational mechanisms influencing intra-breath gas concentration gradients and oscillations.
    • Further analysis of microgravity data from SLS-1, D-2, and SLS-2 missions will be fruitful for understanding these mechanisms.