Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Respiratory correlated cone beam CT.

Jan-Jakob Sonke1, Lambert Zijp, Peter Remeijer

  • 1Department of Radiation Oncology, The Netherlands Cancer Institute--Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. j.sonke@nki.nl

Medical Physics
|May 18, 2005
PubMed
Summary

This study introduces a new four-dimensional (4D) cone beam computed tomography (CBCT) method to reduce motion artifacts in image-guided radiotherapy. The novel technique accurately tracks tumor motion, improving treatment precision and safety.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical feasibility of fast adaptive four-dimensional cone-beam computed tomography for lung cancer radiotherapy.

Physics and imaging in radiation oncology·2026
Same author

Simultaneous concurrent chemoradiation and SBRT in stage III NSCLC: Safety report of the phase I hybrid trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Estimation of accumulated dose to organs at risk in head and neck cancer patients treated with scheduled replanning and dose painting in the ARTFORCE trial.

Physics and imaging in radiation oncology·2026
Same author

Dose-based evaluation of delineation variation in radiotherapy: A scoping review.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Acute and long-term toxicity profiles and final oncologic outcomes in the phase III ARTFORCE trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Automated target misalignment correction for cone beam computed tomography-based online adaptive radiotherapy of locally advanced lung cancer patients.

Physics and imaging in radiation oncology·2025

Area of Science:

  • Medical Physics
  • Radiotherapy Technology
  • Image Processing

Background:

  • Respiratory motion significantly degrades image quality in cone beam computed tomography (CBCT) used for image-guided radiotherapy.
  • Existing respiratory-correlated CT methods are not directly applicable to CBCT systems integrated with linear accelerators.
  • Motion artifacts in CBCT can lead to geometric uncertainties in radiation delivery.

Purpose of the Study:

  • To develop and evaluate an alternative respiratory-correlated procedure for CBCT to mitigate motion artifacts.
  • To enable the reconstruction of four-dimensional (4D) CBCT datasets from projection data.
  • To assess the accuracy and effectiveness of the developed 4D CBCT method in phantom and patient studies.

Main Methods:

  • Developed a retrospective sorting technique in projection space to create breathing phase-specific projection subsets.

Related Experiment Videos

  • Reconstructed these subsets into a 4D CBCT dataset.
  • Extracted the breathing signal directly from 2D projection data, eliminating the need for external respiratory monitoring.

    • Main Results:

    • The 4D CBCT procedure successfully reduced motion artifacts compared to standard 3D CBCT.
    • Positional deviations of phantom motion centers were minimal (0.13 +/- 0.09 mm for regular, 0.39 +/- 0.24 mm for irregular motion).
    • The method provided 3D trajectory information of moving structures and demonstrated comparable results in lung cancer patient data, though significant irregularities reduced image quality.

    Conclusions:

    • Successfully implemented a respiratory-correlated CBCT procedure yielding 4D datasets.
    • This 4D CBCT enables pre-treatment verification of tumor position, trajectory, and shape, reducing geometric uncertainties.
    • The technique facilitates safer 4D radiotherapy delivery with reduced margins for moving targets.