Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural changes in the airways in asthma: observations and consequences.

Tony R Bai1, Darryl A Knight

  • 1James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada. tbai@mrl.ubc.ca

Clinical Science (London, England : 1979)
|May 18, 2005
PubMed
Summary

Asthma involves airway structural changes like thickened walls and excess mucus. These alterations, influenced by genetics and inflammation, contribute to breathing difficulties and airway narrowing in patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Senescence intensifies bleomycin-induced injury in idiopathic pulmonary fibrosis lung epithelial cells.

ERJ open research·2026
Same author

Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease.

Molecular therapy : the journal of the American Society of Gene Therapy·2025
Same author

Alveolar epithelial cells of lung fibrosis patients are susceptible to severe virus-induced injury.

Clinical science (London, England : 1979)·2024
Same author

Mechanical forces suppress antiviral innate immune responses from asthmatic airway epithelial cells following rhinovirus infection.

American journal of physiology. Lung cellular and molecular physiology·2023
Same author

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts.

Frontiers in pharmacology·2022
Same author

Conditionally reprogrammed asthmatic bronchial epithelial cells express lower <i>FOXJ1</i> at terminal differentiation and lower <i>IFNs</i> following RV-A1 infection.

American journal of physiology. Lung cellular and molecular physiology·2022

Area of Science:

  • Pulmonary Medicine
  • Respiratory Cell Biology
  • Asthma Pathophysiology

Background:

  • Asthma is characterized by airway inflammation and remodeling.
  • Structural changes in asthmatic airways include epithelial fragility, goblet cell hyperplasia, and increased airway smooth muscle mass.
  • Early life factors and disease duration significantly impact airway remodeling.

Purpose of the Study:

  • To comprehensively review the structural changes occurring in the airways of individuals with asthma.
  • To explore the mechanisms and contributing factors behind airway remodeling in asthma.
  • To understand the relationship between structural alterations and asthma severity, airflow limitation, and hyperresponsiveness.

Main Methods:

  • Review of existing literature on asthma-related airway structural changes.

Related Experiment Videos

  • Analysis of pathological findings in asthmatic airways.
  • Correlation of structural alterations with clinical manifestations and disease progression.

    • Main Results:

    • Key structural changes include epithelial abnormalities, mucus gland hyperplasia, increased matrix deposition, smooth muscle hypertrophy, and wall thickening.
    • Genetic and early-life factors contribute to subepithelial fibrosis, while inflammation drives other alterations.
    • Airway remodeling contributes to fixed airflow limitation and influences airway hyperresponsiveness, with varying effects based on asthma phenotype.

    Conclusions:

    • Airway structural changes are central to asthma pathophysiology, affecting airway function and clinical presentation.
    • These remodeling processes are multifactorial, involving genetic predispositions, environmental exposures, and chronic inflammation.
    • Understanding these structural modifications is crucial for developing targeted therapies for different asthma phenotypes.