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Two membrane juxtaposed signaling modules in ANF-RGC are interlocked

Teresa Duda1, Rameshwar K Sharma

  • 1Unit of Regulatory and Molecular Biology, Department of Cell Biology, SOM and NJMS, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA. dudatm@umdnj.edu

Biochemical and Biophysical Research Communications
|May 18, 2005
PubMed
Summary

The atrial natriuretic factor receptor guanylate cyclase (ANF-RGC) signaling mechanism is re-evaluated. A new model shows the disulfide motif represses activity via the ATP-regulated transduction module (ARM) domain, challenging previous concepts.

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