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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Labdane diterpenes from Marrubium velutinum and Marrubium cylleneum
Anastasia Karioti1, Jörg Heilmann, Helen Skaltsa
1Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, Panepistimiopolis-Zografou, GR-15771 Athens, Greece.
Abstract:
From the aerial parts of Marrubium velutinum and Marrubium cylleneum, seven labdane diterpenes, velutine A, 15-epi-velutine A, velutine B, 15-epi-velutine B, velutine C, cyllenine A and 15-epi-cyllenine A, have been isolated together with five known diterpenes and four known flavones. The structures of the isolated compounds were established by means of NMR [(1)H-(1)H-COSY, (1)H-(13)C-HMQC, HMBC, HMQC-TOCSY, NOESY] and MS spectral analyses. Complete NMR assignments are reported for known compounds.
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