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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Cyclolignans from Scyphocephalium ochocoa via high-throughput natural product chemistry methods
Jin-Feng Hu1, Eliane Garo, Hye-Dong Yoo
1Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 11199 Sorrento Valley Road, Suite H, San Diego, CA 92121, USA. jhu@sequoiasciences.com
Abstract:
Two 2,7'-cyclolignans, ocholignans A and B, were obtained as mass-limited samples from Scyphocephalium ochocoa via high-throughput natural products chemistry methods. The rapid structure elucidation of each compound was primarily facilitated by NMR data acquisition using a capillary-scale NMR probe, CapNMR probe. Ocholignan A was found to possess significant in vitro antibacterial activity against Gram-positive bacteria methicillin-resistant Staphylococcus aureus ATCC 33591 and S. aureus 78-13607A with a MIC of 16 microg/mL, respectively.
