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Life-threatening paraneoplastic cutaneous syndromes
Stephen P Stone1, Lucinda S Buescher
1Division of Dermatology, Southern Illinois University School of Medicine, Springfield, 55026, USA. sstone@siumed.edu
Clinics in Dermatology
|May 18, 2005
Summary
Paraneoplastic syndromes link internal cancers to skin disorders. This review explores specific dermatologic conditions associated with malignancy, aiding in early cancer detection.
Area of Science:
- Dermatology
- Oncology
- Internal Medicine
Background:
- Paraneoplastic syndromes manifest as symptom complexes linked to internal malignancies.
- In dermatology, these syndromes specifically refer to skin disorders associated with underlying cancer.
Purpose of the Study:
- To elucidate the association between internal malignancies and various dermatologic disorders.
- To discuss the known mechanisms underlying these paraneoplastic dermatoses.
Main Methods:
- Review of literature linking specific dermatologic conditions to internal malignancy.
- Discussion of pathomechanisms for selected paraneoplastic dermatoses.
Main Results:
- Established links between malignancy and dermatoses including acanthosis nigricans, acrokeratosis paraneoplastica of Bazex, dermatomyositis, erythema gyratum repens, necrolytic migratory erythema, and paraneoplastic pemphigus.
- Exploration of the underlying mechanisms for these conditions where information is available.
Conclusions:
- Recognizing specific dermatologic disorders can indicate the presence of internal malignancy.
- Understanding these paraneoplastic syndromes is crucial for timely diagnosis and management of associated cancers.