Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aurora kinases.

Victor M Bolanos-Garcia1

  • 1Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1 GA Cambridge, UK. victor@cryst.bioc.cam.ac.uk

The International Journal of Biochemistry & Cell Biology
|May 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of aqueous graphene as a cancer therapeutics delivery system.

Scientific reports·2025
Same author

Mps1 kinase functions in mitotic spindle assembly and error correction.

Trends in biochemical sciences·2025
Same author

Production of SAC Proteins in a Baculovirus-Based Heterologous Gene Expression System.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

The Use of APC/C Antagonists to Promote Mitotic Catastrophe in Cancer Cells.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Targeting APC/C Ubiquitin E3-Ligase Activation with Pyrimidinethylcarbamate Apcin Analogues for the Treatment of Breast Cancer.

Biomolecules·2024
Same author

Overexpression of Endoplasmic Reticulum Proteins from Arabidopsis thaliana in Baculovirus.

Methods in molecular biology (Clifton, N.J.)·2024

Aurora kinases regulate cell division and are over-expressed in many cancers. Inhibitors targeting Aurora A, a serine-threonine kinase, show promise as novel anti-cancer agents, particularly for pancreatic cancer.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Aurora kinases (A, B, and C) are crucial regulators of mitosis, involved in cytokinesis and chromosome segregation.
  • Over-expression of these serine-threonine kinases is frequently observed in various solid tumors.
  • Human Aurora A is a potential drug target, especially in pancreatic cancer.

Purpose of the Study:

  • To highlight Aurora kinases as key regulators of mitosis and their role in cancer.
  • To emphasize human Aurora A as a drugable target.
  • To discuss the implications of Aurora A's unique structural conformation for inhibitor development.

Main Methods:

  • Review of existing literature on Aurora kinase biology and structure.
  • Analysis of the structural features of Aurora A, particularly the activation loop.

Related Experiment Videos

  • Exploration of the therapeutic potential of Aurora kinase inhibitors.

    • Main Results:

    • Aurora kinases play vital roles in cell division processes.
    • Dysregulated expression of Aurora kinases is linked to tumorigenesis.
    • The unique structural conformation of Aurora A facilitates targeted inhibitor design.

    Conclusions:

    • Aurora kinases are critical targets for anti-cancer drug development.
    • Inhibitors targeting Aurora kinases, especially Aurora A, hold promise as novel antioncogenic agents.
    • Structural insights into Aurora A are driving the development of new cancer therapies.