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Updated: Aug 12, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 7, 2010
How might cohesin hold sister chromatids together?
1IMP (Research Institute of Molecular Pathology), Dr Bohr-Gasse 7, A-1030 Vienna, Austria. knasmyth@imp.univie.ac.at
Abstract:
The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.
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