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Related Experiment Videos

Brain lesions and eating disorders.

R Uher1, J Treasure

  • 1PO59 Eating Disorders Unit, Institute of Psychiatry, King's College London, De Crespigny Park, London, SE5 8AF, UK. r.uher@iop.kcl.ac.uk

Journal of Neurology, Neurosurgery, and Psychiatry
|May 18, 2005
PubMed
Summary

Brain damage in specific right-sided frontal and temporal lobes is linked to eating disorders. This challenges the traditional view that hypothalamic damage causes these conditions, suggesting frontotemporal circuits play a key role.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neurology

Background:

  • Eating disorders are complex mental illnesses with unclear neurobiological underpinnings.
  • Traditional research has often focused on hypothalamic dysfunction in the aetiology of eating disorders.

Purpose of the Study:

  • To investigate the association between brain lesions in specific structures and the development of eating disorders.
  • To inform neurobiological research on the causes of eating disorders.

Main Methods:

  • Systematic review of 54 published case reports involving individuals with eating disorders and brain damage.
  • Analysis of lesion location, associated psychopathology, and evidence for a causal link.

Main Results:

  • Hypothalamic and brain stem lesions are associated with basic appetite and eating behavior changes.
  • Complex eating disorder syndromes, including characteristic psychopathology, are linked to damage in the right frontal and temporal lobes.

Conclusions:

  • Findings suggest frontotemporal circuits, particularly in the right hemisphere, are critically involved in the pathogenesis of eating disorders.
  • This challenges the established view implicating hypothalamic disturbances as the primary cause.

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