Related Experiment Video
Updated: Aug 18, 2026
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
Published on: June 14, 2015
Possibilities and limitations of fibrin glue usage in nephron-sparing surgery: experimental study
Ivica Stojkovic1, Vojin Savic, Milan Djokic
1Clinic of Urology, Clinical Center Nis, Nis, Serbia and Montenegro.
Introduction:
The possibilities and limitations of fibrin glue (FG) usage in nephron-sparing surgery were studied.
Materials And Methods:
A prospective experimental study was carried out in 50 pigs: 30 with polar resection, and 20 with mediorenal wedge resection of the kidney. Hemostatic sutures, FG, and FG with a muscle 'cup' in animals with polar resection of the kidney were compared. FG and sutures in animals with the wedge resection of the kidney were studied as well. Bleeding, hot ischemia time, complication rate, and additional scarring were also analyzed.
Results:
Suture hemostasis is safe but with significant adverse effects in both polar and wedge resection of kidney. FG was not efficient as a sole hemostatic agent for polar resection. It was as efficient as hemostatic suture for wedge resection of the kidney. FG with a muscle 'cup' on a pole of the kidney achieved good results in animals with polar resection of the kidney. Histological analysis confirmed better results with FG because of both the less intense and smaller area of additional scarring.
Conclusion:
FG is a reliable and efficient hemostatic agent for nephron-sparing surgery whenever both sided gluing is possible.
More Related Videos
08:05Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
05:30The Combination of Mechanically Isolated Stromal Vascular Fraction and Fibrin Hydrogel: A Processing Protocol
Published on: November 17, 2023