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Neuroimaging and therapeutics in movement disorders
Thomas Eckert1, David Eidelberg
1Department of Neurology II and Psychiatry, University of Magdeburg, Germany.
Summary
Neuroimaging techniques are crucial for evaluating treatments for movement disorders like Parkinson's disease (PD). These methods assess dopaminergic function and network activity, offering objective markers for treatment response in pharmacological and surgical interventions.
Area of Science:
- Neuroscience
- Medical Imaging
- Neurology
Background:
- Movement disorders, particularly Parkinson's disease (PD), present significant challenges in treatment assessment.
- Traditional assessment methods may lack objective markers for treatment efficacy.
Purpose of the Study:
- To review the role of neuroimaging in assessing treatment options for movement disorders.
- To highlight how imaging provides objective markers for treatment response.
Main Methods:
- Discussion of neuroimaging methods assessing dopaminergic function.
- Review of imaging techniques evaluating regional metabolism and cerebral perfusion.
- Application of these methods in clinical trials for neuroprotective agents and network activity modulation.
Main Results:
- Neuroimaging of dopaminergic function is applied in trials for neuroprotective agents.
- Imaging of metabolism/perfusion quantifies network activity modulation as an objective treatment response marker.
- Both strategies offer novel insights into treatment mechanisms for PD and other movement disorders.
Conclusions:
- Neuroimaging plays a vital role in evaluating treatments for movement disorders.
- Objective markers derived from imaging enhance understanding of treatment mechanisms.
- These advancements benefit both pharmacological and surgical treatment strategies for PD.