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Pyridoxamine (BioStratum).

Nick Giannoukakis¹

¹University of Pittsburgh School of Medicine, Diabetes Institute, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA. ngiann1@pitt.edu

Current Opinion in Investigational Drugs (London, England : 2000)

|May 19, 2005

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BioStratum is investigating pyridoxamine (Pyridorin) to prevent diabetic nephropathy by inhibiting advanced glycation end-products (AGEs). Phase II trials were completed by January 2004, showing potential for this therapeutic approach.

Area of Science:

Nephrology
Pharmacology
Endocrinology

Background:

Diabetic nephropathy is a significant complication of diabetes.
Advanced glycation end-products (AGEs) play a key role in diabetic nephropathy pathogenesis.
Pyridoxamine (Pyridorin) is an inhibitor of AGE formation.

Purpose of the Study:

To evaluate the potential of pyridoxamine (Pyridorin) in preventing diabetic nephropathy.
To assess the safety and efficacy of Pyridorin in preclinical and early clinical studies.

Main Methods:

Development of pyridoxamine (Pyridorin) as an AGE inhibitor.
Completion of Phase II clinical trials by January 2004.

Main Results:

Phase II trials for Pyridorin were completed.

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Data from trials indicate potential efficacy in preventing diabetic nephropathy.

Conclusions:

Pyridoxamine (Pyridorin) shows promise as a preventative treatment for diabetic nephropathy.
Further clinical investigation is warranted to confirm the therapeutic benefits of Pyridorin.