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Evening primrose oil effects on osteoclasts during tooth movement
Suwimol Taweechaisupapong1, Nitipavee Srisuk, Chawalit Nimitpornsuko
1Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen 40002, Thailand. suvi_taw@kku.ac.th
The Angle Orthodontist
|May 19, 2005
Summary
Evening primrose oil (EPO) supplementation increased osteoclast numbers during experimental tooth movement in rats. This suggests EPO may accelerate orthodontic tooth movement by enhancing bone remodeling processes.
Area of Science:
- Orthodontics
- Oral Biology
- Pharmacology
Background:
- Osteoclast differentiation and activity are crucial for orthodontic tooth movement.
- Evening primrose oil (EPO) is known for its anti-inflammatory properties, but its effect on bone remodeling during tooth movement is not well understood.
Purpose of the Study:
- To investigate the influence of oral evening primrose oil (EPO) supplementation on osteoclast expression during experimental tooth movement in a rat model.
Main Methods:
- Forty-eight male Sprague-Dawley rats were divided into experimental (EPO-fed) and control (water-fed) groups.
- EPO was administered orally for 20 days prior to applying a mesial tipping force to the maxillary first molar.
- Osteoclast counts were assessed on days 0, 3, 7, and 14 post-loading.
Main Results:
- A significant increase in osteoclast numbers was observed on the appliance side on day 3 in the EPO group compared to controls (P < .05).
- Osteoclast numbers were also significantly higher on the non-appliance side on day 7 in the EPO group (P < .05).
Conclusions:
- Oral administration of evening primrose oil (EPO) increases osteoclast numbers during experimental tooth movement in rats.
- EPO supplementation may potentially accelerate orthodontic tooth movement by modulating osteoclast activity and bone resorption.