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Hereditary peromelia in Mohair goats
1Department of Pathology and Epidemiology, National Veterinary Laboratory, Copenhapen, Denmark.
Zentralblatt Fur Veterinarmedizin. Reihe A
|March 1, 1992
Summary
A novel congenital limb defect, peromelia, is identified in Mohair goats. This autosomal recessive condition affects limb development, with a predisposition for pelvic limbs.
Area of Science:
- Veterinary Genetics
- Congenital Malformations
- Animal Orthopedics
Background:
- Congenital defects can significantly impact animal health and breeding.
- Peromelia, a limb malformation, has been documented in various species.
- Understanding the genetic basis of skeletal defects is crucial for effective management.
Purpose of the Study:
- To describe a newly identified congenital appendicular skeletal defect in Mohair goats.
- To investigate the inheritance pattern and phenotypic characteristics of this defect.
- To compare the defect with similar conditions in other livestock.
Main Methods:
- Pathological examination of 8 affected goats.
- Clinical examination of 1 affected goat.
- Owner-reported data collection for 5 additional cases.
Main Results:
- The defect, termed peromelia, involves agenesis of phalanges and parts of the metacarpus/metatarsus.
- An autosomal recessive mode of inheritance is suggested, with variable expressivity.
- Pelvic limbs showed a higher predisposition to be affected.
- Additional skeletal abnormalities were noted in some cases.
Conclusions:
- A novel congenital limb defect, peromelia, is characterized in Mohair goats.
- The defect exhibits an autosomal recessive inheritance pattern.
- Phenotypic similarities suggest a possible genetic homology with a similar defect in sheep.