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Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)
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Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)

Published on: December 16, 2021

Magnetic resonance imaging in experimental subarachnoid haemorrhage

W M van den Bergh1, J Schepers, W B Veldhuis

  • 1Department of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands. w.m.vanderbergh@neuro.azu.nl

Acta Neurochirurgica
|May 19, 2005
PubMed
Abstract

Insights

This study demonstrates that MRI can detect changes in rat cerebrovascular diameter and blood flow after subarachnoid hemorrhage (SAH), revealing vasoconstriction and delayed cerebral ischemia.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Vascular Biology

Background:

  • Subarachnoid hemorrhage (SAH) can lead to secondary brain injury.
  • Detecting early cerebrovascular changes after SAH is crucial for understanding and treating cerebral ischemia.

Purpose of the Study:

  • To develop and validate an MRI protocol for measuring cerebrovascular diameter and blood flow velocity.
  • To investigate cerebrovascular alterations and their impact on cerebral ischemia following experimental SAH in rats.

Main Methods:

  • SAH was induced in Wistar rats using the endovascular filament method.
  • MRI measurements, including diffusion-weighted, T2-weighted, arterial spin labeling (ASL), and MR angiography, were performed at specific time points post-SAH.
  • Cerebral blood flow (CBF), vessel diameter, and blood flow velocity were quantified.

Main Results:

  • Ischemic lesion volume significantly increased from 1 to 48 hours post-SAH.
  • Cerebral blood flow (CBF) decreased significantly after SAH.
  • Vasoconstriction was observed in cerebral vessels, with a significant reduction in the internal carotid artery diameter.
  • Baseline values for most parameters were restored by day 9.

Conclusions:

  • The developed MRI protocol is effective in detecting in-vivo cerebrovascular alterations and their consequences after experimental SAH in rats.
  • Delayed cerebral ischemia following SAH in rats is suggested to be linked to vasoconstriction.
  • These findings highlight the potential of MRI in monitoring SAH-induced vascular changes and brain damage.

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