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Updated: Aug 13, 2026

piggyBac Transposon System Modification of Primary Human T Cells
Published on: November 5, 2012
TRAV gene usage in pig T-cell receptor alpha cDNA
Ryuji Yamamoto1, Hirohide Uenishi, Hiromi Hatsuse
1Genome Research Department, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, 305-8602, Japan.
Abstract:
Pig (Sus scrofa) TRA clones were isolated from cDNA libraries of total RNA from two different sources, the thymus of a 1-month-old LW strain pig and the peripheral blood lymphocytes of a 5-month-old Clawn strain pig. Among 103 complete TRA cDNA clones from both sources, 33 different TRAV genes were identified. By comparing their sequence identities against one another, these pig TRAV genes were grouped into 20 subgroups, including 13 subgroups, each containing only a single member. All of these pig subgroups gave corresponding human and mouse functional counterparts, suggesting their functional commonality. An exception was the Va01 gene segment, which lacked a functional human counterpart. The present report provides groundwork for studies on pig TRA expression.
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