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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Lymphocyte-rich Hassall bodies in the normal human thymus
Marius Raica1, Anca Maria Cimpean, Svetlana Encica
1Department of Histology and Cytology, "Victor Babes" University of Medicine and Pharmacy, RO-300041 Timisoara, Romania. raica@umft.ro
Abstract:
The study is concerned with the presence of an unusual Lymphocyte-rich type of Hassall body in the normal human thymus. Lymphocyte-rich Hassall bodies are large, they are usually lined by squamous epithelial cells, and contain closely packed lymphocytes in areas with necrotic and hyaline material. Lymphocyte-rich areas of the HassaLL bodies do not contain epithelial cells (as demonstrated with cytokeratin 8/18, 7, 34betaE12, and MNF116), they were negative for CD20 and S100 protein. Immunoreaction for CD3 was positive in 3 of 4 cases. Our results suggest that this type of Hassall body may be involved in the negative selection of thymocytes.
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