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Preterm birth in Sweden 1973-2001: rate, subgroups, and effect of changing patterns in multiple births, maternal age,
Nils-Halvdan Morken1, Karin Källen, Henrik Hagberg
1Department of Obstetrics and Gynecology, Telemark Hospital, Skien, Norway. nhmorken@online.no
Insights
Sweden
Area of Science:
- Reproductive Health
- Public Health Surveillance
Background:
- Examined trends in preterm birth rates in Sweden from 1973-2001.
- Described the proportion of spontaneous versus indicated preterm births.
- Assessed risk factors for preterm birth subgroups.
Purpose of the Study:
- To evaluate changes in the preterm birth rate in Sweden between 1973 and 2001.
- To describe the proportion of spontaneous and indicated preterm births.
- To assess risk factors for preterm birth subgroups from 1991 to 2001.
Main Methods:
- Population-based register study using the Swedish Medical Birth Register (1973-2001).
- Subgroup analysis focused on 1991-2001.
- Calculated odds ratios for risk factors associated with spontaneous and indicated preterm births.
Main Results:
- Preterm birth rate decreased from 6.3% (1984) to 5.6% (2001).
- Proportion of multiple births born preterm increased from 0.34% (1973) to 0.71% (2001).
- Maternal smoking strongly associated with spontaneous preterm birth (<28 weeks gestation); advanced maternal age associated with indicated preterm birth (<28 weeks gestation).
Conclusions:
- Preterm birth rates in Sweden have declined since the mid-1980s.
- Subtype composition of preterm births in this low-risk population mirrors that of higher-incidence populations.
Background:
The objectives of this report are to evaluate changes in the preterm birth rate in Sweden 1973-2001. Furthermore, describe the proportion of spontaneous and indicated preterm births and assess risk factors for the subgroups of preterm birth during the period from 1991 to 2001.
Methods:
A population-based register study of all births occurring in Sweden from 1973 to 2001 registered in the Swedish Medical Birth Register was designed. The analysis of subgroups was restricted to the period 1991-2001. Gestational age was calculated using last menstrual period and best estimate. Odds ratio for preterm birth related to risk factors was calculated for the subgroups' spontaneous and indicated preterm birth.
Results:
After an increase in the beginning of the 1980s, the preterm birth rate has decreased from 6.3% in 1984 to 5.6% in 2001 (P < 0.0001). The proportion of multiple births born preterm of the total birth rate increased from 0.34% in 1973 to 0.71% in 2001 (P < 0.0001). Spontaneous preterm births account for 55.2% and iatrogenic preterm births for 20.2% of all preterm births. The strongest association with maternal smoking in early pregnancy was found at gestational age <28 weeks and spontaneous preterm birth [odds ratio (OR) smoking versus no smoking: 1.55, 95% confidence intervals (CI): 1.42-1.69]. The strongest association for maternal age was found between gestational age <28 weeks and indicated preterm birth (OR 5-year increase: 1.34, 95% CI: 1.21-1.47).
Conclusions:
The preterm birth rate in Sweden has decreased since the mid 1980s. The composition of different subtypes of preterm birth in a Scandinavian low-risk population seems to be similar to populations with higher incidence of preterm birth and perinatal infections.
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