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Updated: Aug 18, 2026

Analysis of mRNA Nuclear Export Kinetics in Mammalian Cells by Microinjection
Published on: December 4, 2010
Dynamics of transcription and mRNA export
Xavier Darzacq1, Robert H Singer, Yaron Shav-Tal
1Department of Anatomy, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Abstract:
Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the cytoplasm and translation. We now possess an in-depth understanding of the mechanism and regulations of transcription. By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments.
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