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Updated: Aug 18, 2026

Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis
Published on: September 30, 2017
Evolution of subspecies of Francisella tularensis
Kerstin Svensson1, Pär Larsson, Daniel Johansson
1Department of NBC-Analysis, Swedish Defence Research Agency, SE-901 82 Umeå, Sweden.
Abstract:
Analysis of unidirectional genomic deletion events and single nucleotide variations suggested that the four subspecies of Francisella tularensis have evolved by vertical descent. The analysis indicated an evolutionary scenario where the highly virulent F. tularensis subsp. tularensis (type A) appeared before the less virulent F. tularensis subsp. holarctica (type B). Compared to their virulent progenitors, attenuated strains of F. tularensis exhibited specific unidirectional gene losses.
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