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The effect of multiple cycles in oocyte donors
Akas Jain1, Jared C Robins, Daniel B Williams
1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Cincinnati Medical Center, Ohio, USA. akasjain@hotmail.com
American Journal of Obstetrics and Gynecology
|May 20, 2005
Summary
Repeat controlled ovarian hyperstimulation cycles in oocyte donors do not negatively impact ovarian response or oocyte retrieval. Donors can undergo multiple cycles without affecting pregnancy rates or embryo quality.
Area of Science:
- Reproductive endocrinology and infertility.
- Ovarian physiology and stimulation protocols.
Background:
- Controlled ovarian hyperstimulation (COH) is a key component of in vitro fertilization (IVF) cycles.
- Understanding the long-term effects of repeated COH in oocyte donors is crucial for donor safety and efficacy.
Purpose of the Study:
- To investigate the impact of multiple COH cycles on oocyte donors.
- To assess if repeat cycles affect ovarian response, oocyte yield, or pregnancy outcomes.
Main Methods:
- Retrospective chart review of 107 donor IVF cycles between 1992 and 2003.
- Analysis of cycle parameters including estradiol levels, stimulation duration, follicle count, gonadotropin dosage, oocyte retrieval, and clinical pregnancy rates.
Main Results:
- No significant differences were observed in cycle parameters for donors undergoing second or third COH cycles.
- Analysis included 45 donors with at least two cycles and 17 donors with three cycles.
Conclusions:
- Repeated COH cycles in oocyte donors do not lead to diminished ovarian response to gonadotropins.
- Oocyte donors can safely undergo up to three stimulation cycles without compromising ovarian response, oocyte retrieval, embryo quality, or pregnancy rates.